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4th gen test negative but still hiv symptoms

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  • 4th gen test negative but still hiv symptoms

    Hi Dr, I wonder if you can help. I had exposure to possible hiv2 in 2014 (woman of African origin) . 4+ months after exposure, I had rapid finger prick test which was negative (I think 3rd gen but not sure). I have no further exposure, but in late February this year(2020) I had cold and bad chest and was ill for a few days but after this developed oral thrush on tongue. This is late stage hiv opportunistic infection? I have also had muscle ache and sore throat. Oral thrush for 4 months now. I have had two further self tests (2nd and 3rd) generation, both negative, and a 4th gen lab test (antibody/antigen) test (blood taken from arm) all negative since I got oral thrush. Could the problem be it is not showing positive because of hiv2? Or could I be seronegative? What is best option, further 4th gen test or HIV RNA? Will this pick up what 4th gen hasn't?

    Someone please help I cannot sleep.

  • #2
    Dear Dr, can someone please offer some advice, I am really worried. Continued late stage hiv symptons despite negative test. What type of test should I now go for? Hiv rna for type 1 and type 2?

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    • #3
      Hi Anx01,

      You do not have HIV. 4th Gen HIV Ab/Ag testing will be able to pick up HIV2 as well.

      You might want to speak to your healthcare providers regarding other investigations like blood works or scans for your symptoms.

      Regards

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      • #4
        Dr Zeng. I really appreciate you taking the time to answer my question. It means a great deal. Thank you. I will take your advice and continue to consult my health care provider.

        I got paranoid as all the literature presents oral thrush as meaning hiv? Only immune suppressed get it? In my scenario, I am seronegative, so not picking up hiv2 antibodies. If this were true, and It probably only exists in my mind, but if it were, what test would I need after 4th gen to be sure? A hiv rna/dna specifically for hiv2, as read they usually only look for hiv1?

        I promise no more questions after this. Thank you again.

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        • #5
          Hi Anx01,

          There are many reasons for oral thrush, for which HIV infection is one of those. Other reasons are like poorly controlled diabetes or use of corticosteriods.

          You might consider HIV2 RNA PCR or ProViral DNA testing if you really want to rule out HIV2. I'm not sure whether you have access to these tests in your area though.

          Regards

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          • #6
            Dr Zeng. Thank you so much for your advice. I really appreciate you taking the time. I am based in UK at present, which is where I took hiv 4th gen. It seems to just be focused on HIV 1 RNA PCR here. I will seek advice at clinic.

            Thank you and best wishes.

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