PDE5i For Erectile Dysfunction

Men’s Clinic in Singapore (Caring & Treating Since 2005)

Phosphodiesterase 5 Inhibitors (PDE5i) are a class of medications used to treat Erectile Dysfunction. They are the first line of therapy in men who are present with symptoms of having poor quality of erections. As mentioned in our previous articles, a healthy erection is one of the cornerstones of male reproductive health– Men’s Health Clinic Singapore

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Not all PDE5i are made the same, understanding how each one works will allow better discussion with your attending physician when deciding which medication will work best for your situation. In general, inhibition of PDE enzymes in the body results in the dilatation of blood vessels throughout the body. Consequently, medications such as PDE5i that enhance erections can lead to unwanted side effects of headaches and back pain. Medical research therefore has been focused on creating ED medications that are more focused on inhibition PDE5 only in order to enhance erections with minimal side effects.

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Highly Specific PDE5i

Highly specific PDE5 inhibitors can offer the potential benefits of providing good quality erections with minimal side effects. Studies have shown that this inhibitor is 110-fold more selective to PDE5 than other similar medications. Additionally, it is known for its faster absorption compared to others in its class, leading to a quicker onset of action within 30 to 45 minutes. Large clinical studies involving 600 patients have demonstrated significant improvements in erection quality with specific doses.

Despite its specificity, this medication still shares common side effects with others in its class, such as headaches, flushing, and nasal congestion. The absorption of this medication can also be influenced by the consumption of fatty foods, resulting in a 20% decrease in absorption and a subsequent one-hour delay in onset.

As a valuable addition to the family of medications for erectile dysfunction (ED), this inhibitor requires a doctor’s prescription for use. Consulting with your healthcare provider about any concerns you may have can facilitate the development of a tailored treatment plan to improve erectile function and enhance overall reproductive health.

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Speak to our doctor today to find out if PDE5i is suitable for you.

PDE5i is available at our clinics.


  1. Mehrotra N, Gupta M, Kovar A, Meibohm B. The role of pharmacokinetics and pharmacodynamics in phosphodiesterase-5 inhibitor therapy. Int J Impot Res. 2007;19:253-264
  2. Goldstein I, McCullough AR, Jones LA et al. A randomized, double-blind, placebo-controlled evaluation of the safety and efficacy of  ED pills in subjects with erectile dysfunction. J Sex Med. 2012;9:1122-1133

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